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pentobarbital will reduce the level or effect of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Stay clear of coadministration of lefamulin with potent or reasonable CYP3A inducers Unless of course the gain outweighs dangers. Keep track of for reduced efficacy.Keep an eye on Carefully (1)pe